Amidinophenol derivatives

Details Amidinophenol derivatives Amidinophenol derivatives

C - Chemistry, Metallurgy

07

C

C07C 257/18 (2006.01) A61K 31/24 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) C07C 323/51 (2006.01) C07D 209/20 (2006.01) C07D 209/86 (2006.01) C07D 215/14 (2006.01)

Patent

CA 2137106

Amidinophenol derivatives of the formula (I) and acid-addition salts thereof (in which R1 and R2 are alkyl, alkoxy, acyl, halogen, nitro, benzoyl, COOR4: A is bond, alkylene, group of the formula (II): R3 is group of the formula (III), (IV)) (see formulas I, II, III, IV) have inhibitory activities on phospholipase A2 and proteases (especially trypsin), and are useful for the prevention and/or the treatment of inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis, severity in pancreatitis and multiple organ failure.

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