Amide derivatives which are useful as cytokine inhibitors

Details Amide derivatives which are useful as cytokine inhibitors Amide derivatives which are useful as cytokine inhibitors

C - Chemistry, Metallurgy

07

C

C07C 237/42 (2006.01) A61K 31/167 (2006.01) A61K 31/395 (2006.01) C07D 215/48 (2006.01) C07D 295/135 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2337770

The invention concerns amide derivatives of the Formula (I) wherein R3 is (1- 6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno-(1-6C)alkyl, hydroxy-(1-6C)alkyl, di-[(1-6C)akyl]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1- 6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocy-clyl-(1-6C)alkoxy; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and R4 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatement of diseases or medical conditions mediated by cytokines.

L'invention concerne des dérivés d'amides représentés par la formule (I) dans laquelle R<3> est l'alkyle (C1-6) ou halogéno; Q est l'aryle ou l'hétéroaryle comprenant éventuellement 1, 2, 3 ou 4 substituants tels que hydroxy, halogéno, trifluorométhyle, cyano, alkyle (C1-6) alcoxy (C1-6), halogéno-alkyle (C1-6), hydroxyalkyle (C1-6), di-[alkyle (C1-6)]amino-alkyle (C1-6), hydroxy-alcoxy(C2-6), alcoxy(C1-6)-alcoxy(C2-6), di-[alkyle(C1-6)]amino-alcoxy(C2-6), amino-alkyl(C2-6)amino, <u>N</u>-alkyl(C1-6)alkyl(C1-6)amino-alkyl(C2-6)amino, aryle, aryl-alcoxy (C1-6), hétéroaryle, hétéroaryl-alcoxy(C1-6), hétérocyclyle, hétérocyclyle-alkyle(C1-6), hétérocyclyloxy et hétérocyclyl-alkoxy(C1-6); p est 0-2 et R<2> est un substituant tel qu'hydroxy ou halogéno; q est 0-4; et R<4> comprend l'aryle, le cycloalkyle, l'hétéroalkyle et l'hétérocyclyle éventuellement substitués ou des sels pharmaceutiquement acceptables; ou des esters clivables in vivo de ces dérivés. L'invention concerne également des procédés permettant la préparation de ces dérivés, des compositions pharmaceutiques les contenant, ainsi que l'utilisation de ces dérivés pour le traitement de pathologies ou de troubles à médiation de cytokines.

Affiliated with

Also associated with

Rating

Amide derivatives which are useful as cytokine inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amide derivatives which are useful as cytokine inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amide derivatives which are useful as cytokine inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2068950