A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/22 (2006.01)
Patent
CA 2322018
The invention concerns a novel use of VIP analogues for preventing and/or treating brain damage in a human foetus, baby or infant. Said VIP analogue is selected from the group consisting of cyclic VIP analogues and non-cyclic VIP derivatives of 28 amino acids comprising in N-terminal position a N-acetyl group, then Glu in position 8 (Glu<8>), Lys in position 12 (Lys<12>), polyclonal goat in position 17 (Nle<17>), Ala in position 19 (Ala<19>), X1 in position 21, X2 in position 25, Leu in position 26 (Leu<26>), Lys in position 27 and 28 (Lys<27> and Lys<28>), Gly in position 29 and 30 (Gly<29> and Gly<30>) and Thr in position 31 (Thr<31>), X1 representing Lys (Lys<21>) or Nle (Nle<21>) and X2 representing Asp (Asp<25>) or Asn (Asn<25>).
Nouvelle utilisation d'analogues du VIP, dans la prévention et/ou le traitement des lésions cérébrales du foetus, du nouveau-né ou du jeune nourrisson humains. Ledit analogue du VIP est sélectionné dans le groupe constitué par les analogues cycliques du VIP et des dérivés du VIP non cycliques de 28 aminoacides comprenant en position N- terminale un groupe N-acétyle, puis Glu en position 8(Glu8), Lys en position 12 (Lys12), norleucine en position 17 (Nle17), Ala en position 19 (Ala19), X1 en position 21, X2 en position 25, Leu en position 26 (Leu26), Lys en positions 27 et 28 (Lys27 et Lys28), Gly en positions 29 et 30 (Gly29 et Gly30) et Thr en position 31 (Thr 31), X1 représentant Lys (Lys21) ou Nle (Nle21) et X2 représentant Asp (Ase) ou Asn (Asn25).
Gressens Pierre
Robberecht Patrick
Assistance Publique - Hopitaux de Paris
Borden Ladner Gervais Llp
LandOfFree
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