Human mage-like protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2275975

The present invention provides a human MAGE-like protein (MAGELP) and polynucleotides which identify and encode MAGELP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding MAGELP and a method for producing MAGELP. The invention also provides for agonists, antibodies, or antagonists specifically binding MAGELP, and their use, in the prevention and treatment of diseases associated with expression of MAGELP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding MAGELP for the treatment of diseases associated with the expression of MAGELP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding MAGELP.

La présente invention concerne une protéine humaine de type MAGE (MAGELP) et des polynucléotides identifiant et codant la MAGELP. L'invention concerne également des vecteurs d'expression et des cellules hôtes mis au point par génie génétique, comprenant les séquences d'acide nucléique codant la MAGELP, ainsi qu'un procédé de production de la MAGELP. L'invention concerne, en outre, des agonistes, des anticorps ou des antagonistes spécifiquement liés à la MAGELP, et leur utilisation pour la prévention et le traitement de maladies associées à l'expression de la MAGELP. Par ailleurs, on a prévu l'utilisation de molécules anti-sens dirigées contre des polynucléotides codant la MAGELP pour traiter les maladies associées à l'expression de la MAGELP. L'invention prévoit aussi des méthodes diagnostiques pour lesquelles on utilise le polynucléotide, ou des fragments ou le complément de celui-ci, et des anticorps spécifiquement liés à la MAGELP.

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