C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/0783 (2010.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) C12N 15/867 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01) C07K 14/78 (2006.01)
Patent
CA 2233316
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
Un procédé pour améliorer l'efficacité de la traduction de cellules hématopoïétiques et d'autres cellules par des rétrovirus consiste à infecter les cellules en présence de fibronectine ou de fragments de fibronectine. La fibronectine ou les fragments de fibronectine augmentent d'une manière significative le transfert de gènes, à médiation rétrovirale, dans les cellules, en particulier dans des cellules hématopoïétiques comprenant des précurseurs choisis et des cellules souches hématopoïétiques primitives. L'invention concerne également des procédés améliorés de thérapie génique somatique permettant un transfert de gènes amélioré, des populations de cellules hématopoïétiques et de nouveaux produits de recombinaison pour améliorer le transfert par médiation rétrovirale dans des cellules et leur utilisation.
Indiana University Foundation
Indiana University Research And Technology Corporation
Smart & Biggar
LandOfFree
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