C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/57 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2351587
The present invention is directed to recombinant viruses containing a therapeutic transgene operably linked to a late regulatory element. The vectors of the present invention are capable of replication and lysis of neoplastic cells. The vectors may optionally include modifications to the genome so as to impart additional therapeutic, conditionally replicating or targeting functions. The present invention also provides pharmaceutical formulations of such vectors. The present invention further provides methods of use of such vectors. The present invention further provides methods of preparing the vectors.
La présente invention concerne des virus recombinés contenant un transgène thérapeutique lié fonctionnellement à un élément régulateur tardif. Les vecteurs de la présente invention sont capables d'une réplication et d'une lyse de cellules néoplasiques. Les vecteurs peuvent comprendre facultativement des modifications apportées au génome de manière à conférer des fonctions de réplication ou de ciblage thérapeutique conditionnelles supplémentaires. La présente invention concerne également des formulations pharmaceutiques de ces vecteurs. En outre, la présente invention concerne des méthodes d'utilisation de ces vecteurs et des méthodes de préparation des vecteurs.
Canji Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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