Cyanine dyes conjugated with antibodies for the diagnosis of...

Details Cyanine dyes conjugated with antibodies for the diagnosis of... Cyanine dyes conjugated with antibodies for the diagnosis of...

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2573783

This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and/or rheumatoid arthritis, endometriotic lesions, and ocular diseases associated with angiogenesis.

Cette invention concerne l'utilisation de conjugués de colorants à base de cyanine avec un constituant de liaison spécifique à l'angiogenèse, de préférence avec un constituant de liaison spécifique à la fibronectine EB-D, pour le diagnostic d'une micrométastase ou de petites lésions proliférantes, en particulier des tumeurs primitives, des précancers, la dysplasie, la métaplasie, les lésions inflammatoires telles que le psoriasis, l'arthrite psoriatique et/ou l'arthrite rhumatoïde, les lésions endométriotiques, et les maladies oculaires associées à l'angiogenèse.

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