Oncolytic virus for purging cellular compositions of cells...

Details Oncolytic virus for purging cellular compositions of cells... Oncolytic virus for purging cellular compositions of cells...

A - Human Necessities

61

K

A61K 35/28 (2006.01) A61K 35/14 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C12N 7/02 (2006.01)

Patent

CA 2436196

The present invention relates to a method for removing cells of a lymphoid malignancy from a mixed cellular composition using a virus that selectively replicates in cells of the lymphoid malignancy. A variety of viruses can be used to practice the invention, including but not limited to reovirus, adenovirus, and herpesvirus. The invention is particularly useful for purging mixed cellular compositions comprising hematopoietic stem of cells of lymphoid malignancies prior to reintroduction or transplantation into an animal.

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