Nitrile derivatives as cathepsin k inhibitors

Details Nitrile derivatives as cathepsin k inhibitors Nitrile derivatives as cathepsin k inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/401 (2006.01) A61K 31/403 (2006.01) A61K 31/426 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) C07D 207/16 (2006.01) C07D 207/48 (2006.01) C07D 209/52 (2006.01) C07D 263/16 (2006.01) C07D 277/06 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2395179

The present invention relates to compounds of formula (I), wherein R1 to R7 and Y are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cystein proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.

L'invention concerne les composés représentés par la formule (I), où R?1¿ à R?7¿ et Y sont, comme définis dans la description et les revendications, des sels pharmaceutiquement acceptables et/ou des esters pharmaceutiquement acceptables de ceux-ci. Ces composés s'avèrent utiles dans le traitement de maladies associées aux cystéines protéases, telles que l'ostéoporose, l'ostéo-arthrite, l'arthrite rhumatoïde, les métastases de tumeurs, la glomérulonéphrite, l'athérosclérose, l'infarctus du myocarde, l'angine de poitrine, l'angine de poitrine instable, l'apoplexie, la rupture de plaques, les accidents ischémiques transitoires, l'amaurose transitoire, les maladies artérielles oblitérantes périphériques, la resténose après angioplastie et placement de stent, l'anévrisme de l'aorte abdominale, les inflammations, les maladies auto-immunes, la malaria, les modifications cytophatiques des tissus du fond de l'oeil et les maladies respiratoires.

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