Structural nucleic acid guided chemical synthesis

Details Structural nucleic acid guided chemical synthesis Structural nucleic acid guided chemical synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2587010

Disclosed is a composition comprising a nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.

L'invention concerne une composition qui comprend un acide nucléique et un composé chimique, ladite composition formant une structure en étoile à trois ou plus de trois branches qui s'étendent depuis un centre de réaction. Les branches sont constituées par un complexe d'acides nucléiques et le composé chimique est issu du centre de réaction comme produit de réaction de trois ou plus de trois groupes chimiques. L'avantage d'une telle composition est qu'elle offre une proximité étroite enter les groupes chimiques dans le centre de réaction, ce qui favorise une réaction. On décrit également un procédé d'élaboration correspondant, qui offre l'avantage de ne pas nécessiter de présynthèse d'un grand nombre de gabarits et qui ne dépend pas de la reconnaissance codon/anti-codon pour la formation d'une molécule codée.

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