Process for the manufacture of an indolinone derivative

Details Process for the manufacture of an indolinone derivative Process for the manufacture of an indolinone derivative

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01)

Patent

CA 2706423

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)- methylcarbonyl)-N-methyl-amino)-anilino)-1- phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.

La présente invention porte sur un procédé de fabrication d'un dérivé d'indolinone spécifique et sur un sel pharmaceutiquement acceptable de celui-ci, à savoir la 3-Z-[1-(4-(N-((4-méthylpipérazin-1-yl)-méthylcarbonyl)-N-méthylamino)anilino)-1-phénylméthylène]-6-méthoxycarbonyl-2-indolinone et son monoéthanesulfonate, sur de nouvelles étapes de fabrication et sur de nouveaux intermédiaires de ce procédé.

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