Saponin extract from saponaria spp. and uses thereof

Details Saponin extract from saponaria spp. and uses thereof Saponin extract from saponaria spp. and uses thereof

A - Human Necessities

61

K

A61K 36/36 (2006.01) A61K 31/575 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2719555

A saponin extract from Saponaria vaccaria and its use for stimulating apoptosis in cancer cells and treating cancer is described. The saponin extract may be isolated from Saponaria vaccaria seed. The saponin extract may comprise one or more than one triterpene saponin. The triter-pene saponin may comprise a bisdesmosidic saponin having a molecular weight selected from the group consisting of molecular weight 1448, 1464, 1422, 1526, 1596 and 1688. Bisdesmosidic saponin of molecular weight 1448, 1464, 1422, 1526, 1596 and 1688 isolated from Saponaria vac-caria seed may be used to treat human cancer in-cluding prostate cancer, human breast cancer and colon cancer. Also disclosed is a method of isolat-ing the saponin extract.

L'invention porte sur un extrait de saponine provenant de Saponaria vaccaria et sur son utilisation pour stimuler l'apoptose des cellules cancéreuses et traiter le cancer. L'extrait de saponine peut être isolé à partir de graines de Saponaria vaccaria. L'extrait de saponine peut comprendre une ou plus d'une saponine triterpène. La saponine triterpène peut comprendre une saponine bisdesmosidique ayant une masse moléculaire choisie dans le groupe constitué par les masses moléculaires 1448, 1464, 1422, 1526, 1596 et 1688. La saponine bisdesmosidique de masse moléculaire 1448, 1464, 1422, 1526, 1596 et 1688 isolée à partir de graines de Saponaria vaccaria peut être utilisée pour traiter un cancer humain comprenant le cancer de la prostate, le cancer du sein humain et le cancer du côlon. L'invention porte également sur un procédé d'isolement de l'extrait de saponine.

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