C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.04
C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/113 (2006.01) C07K 7/14 (2006.01) C07K 14/645 (2006.01) C07K 14/66 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1140116
Therepeutically active polypeptides or acid addition salts thereof and a process for producing such compounds. A B S T R A C T Polypeptide derivatives of the formula: a - x - y - arg - leu - d wherein x represents a bond, a single amino acid or a pep-tide having up to 10 amino acids in the chain, y represents gln- glu or glu, a represents hydrogen or a small protective group for the .alpha.-amino group in the N-terminal amino acid, d represents -NR1R2, wherein R1 and R2 are selected from the group consisting of hydrogen, C1-C6 alkyl and C3-C8 cycloalkyl, or R1 and R2 together with the attached nitrogen atom form a heterocyclic group optionally containing an additional hetero atom, or d represents -OR3, wherein R3 is selected from the group consisting of hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, benzyl, substituted benzyl, phenacyl, phthalimidomethyl, .beta.-methylthio- ethyl, and 4-picolyl or acid addition salts of such peptides, maybe produced by peptide synthesis methods known per se. The polypeptides potentiate the glucose stimulated secretion of insulin from Langerhans's islets.
336681
Kofod Hans
Nordisk Insulinlaboratorium
Swabey Ogilvy Renault
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