Use of epigallocatechin-gallate for inhibiting angiogenesis

Details Use of epigallocatechin-gallate for inhibiting angiogenesis Use of epigallocatechin-gallate for inhibiting angiogenesis

A - Human Necessities

61

K

A61K 31/353 (2006.01) A61K 8/49 (2006.01) A61K 8/97 (2006.01) A61K 45/06 (2006.01) A61K 45/08 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2366621

The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.

Cette invention se rapporte à un procédé servant à inhiber l'angiogenèse dans des tissus de mammifères, ce procédé consistant à appliquer sur ces tissus une composition comprenant une quantité efficace d'épigallocatéchine-gallate, d'épicathéchine-gallate ou d'une combinaison de celles-ci. Ce procédé est particulièrement utile dans le traitement des pathologies de la peau liées à l'angiogenèse, où la cathéchine est appliquée topiquement, comme c'est le cas dans le traitement de divers cancers de la peau, du psoriasis, des varicosités en araignée ou des cernes sous les yeux.

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