Fluorinated 4-aminoandrostadienone derivatives and process...

Details Fluorinated 4-aminoandrostadienone derivatives and process... Fluorinated 4-aminoandrostadienone derivatives and process...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2118317

2118317 9419365 PCTABS00033 The present invention relates to compounds of formula (I) wherein (x) and (y) are single or double bonds; A is (1) or (2); R and R3 are hydrogen or acyl; R1 is hydrogen or fluorine; and wherein: when (y) is a single bond, R2 is hydrogen, fluorine methyl, trifluoromethyl; when (y) is a double bond, R2 is methylene provided that when one of (x) or (y) is a double bond the other is a single bond and at least one of R1 and R2 is fluorine or trifluoromethyl and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as aromatase inhibitors.

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