Cellular attachment to trans-epithelial appliances

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/00 (2006.01) A61L 27/00 (2006.01) A61L 29/00 (2006.01) A61L 31/00 (2006.01)

Patent

CA 2201492

A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix of a soluble factor isolated from the conditioned medium. The appliance will be useful for dimininishing inflammation and/or infection at the site of entry of the appliance. The applicance may also be used to stimulated gum junctional epithelium adhesion in the treatment of gingivitis and periodontitis. The composition may be used to maintain tissues ex vivo.

Appareil trans-épithélial présentant une composition à base de protéines provoquant la formation d'un hémidesmosome, préparée à partir de cellules d'épithéliome de la vessie du rat. Cette composition stimule la fixation cellulaire et peut être soit la matrice cellulaire, soit un facteur soluble isolé du milieu conditionné. Cet appareil permet de limiter l'inflammation et/ou l'infection au niveau de sa zone de pénétration. On peut également l'utiliser afin de stimuler l'adhésion de l'épithélium au niveau de la jonction de la gencive dans le traitement de la gingivite et de la desmodontite. On peut utiliser la composition afin de maintenir des tissus ex vivo.

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