A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) C07D 215/00 (2006.01)
Patent
CA 2569402
The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., DF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
L'invention concerne des compositions, des préparations pharmaceutiques, et des méthodes pouvant augmenter l'activité (p. ex. le transport ionique) de la protéine mutante régulatrice de la perméabilité transmembranaire de la fibrose kystique (CFTR mutant), par exemple DF508 CFTR, G551D-CFTR, G1349D-CFTR ou D1152H-CFTR, utiles pour le traitement de la fibrose kystique (CF). Les compositions et préparations pharmaceutiques de l'invention peuvent comprendre un ou plusieurs composés contenant phénylglycine, ou des composés contenant sulfonamide, ou un analogue ou un dérivé desdits composés.
Galietta Luis J.v.
Guy R. Kiplin
Pedemonte Nicoletta
Verkman Alan
Fetherstonhaugh & Co.
The Regents Of The University Of California
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