Medical device having hydration inhibitor

Details Medical device having hydration inhibitor Medical device having hydration inhibitor

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2497640

Medical devices comprising an interventional component for delivering multiple beneficial agents in which a hydration inhibitor controls release of at least one beneficial agent from the device. The hydration inhibitor is relatively less hydrophilic than the beneficial agent and preferably is a drug. Suitable beneficial agents include (I) dexamethasone, estradiol, anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs, radiopaque markers, beta-carotene, tocopherols, tocotrienols, and antioxidants

L'invention concerne des dispositifs médicaux comprenant un composant servant à libérer plusieurs agents thérapeutiques. Dans ces dispositifs, un inhibiteur d'hydratation contrôle la libération d'au moins un agent thérapeutique à partir du dispositif. Cet inhibiteur d'hydratation est légèrement mois hydrophile que l'agent thérapeutique et est de préférence un médicament. Les agents thérapeutiques utilisés sont (I) la dexaméthasone, l'estradiol, des agents antiprolifératifs, des agents antiplaquettaires, des agents anti-inflammatoires, des agents antithrombotiques, des médicaments cytotoxiques, des agents qui inhibent la fixation des cytokines ou des chimiokines, des inhibiteurs de la dédifférenciation cellulaire, des agents antilipidémiques, des inhibiteurs des métalloprotéinases matricielles, des médicaments cytostatiques, ou des combinaisons de ces médicaments, des agents de contraste, du bêta-carotène, des tocophérols, des tocotriénols et des antioxydants.

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