A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) B01J 13/02 (2006.01)
Patent
CA 2405787
A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
L'invention concerne un procédé de préparation de microparticules possédant une masse moléculaire polymère recherchée, ce procédé consistant à régler le temps de rétention et la température d'une solution contenant un composé nucléophile et un polymère possédant une masse moléculaire de départ, de manière à régler la masse moléculaire du polymère dans le produit microparticulaire fini. Ainsi, il est possible d'obtenir la masse moléculaire polymère recherchée, dans le produit microparticulaire fini, à partir d'une diversité de masses moléculaires du matériau de départ.
Hotz Joyce M.
Lyons Shawn L.
Ramstack J. Michael
Rickey Michael E.
Wright Steven G.
Alkermes Inc.
Alkermes Controlled Therapeutics Inc. II
Smart & Biggar
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