Gene disruptons, compositions and methods relating thereto

Details Gene disruptons, compositions and methods relating thereto Gene disruptons, compositions and methods relating thereto

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/515 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2638821

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

La présente invention concerne des animaux transgéniques, ainsi que des compositions et des procédés concernant la caractérisation de la fonction génique. De manière spécifique, la présente invention concerne des souris transgéniques comportant des disruptions dans les gènes PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 ou PRO35246. De telles études et caractérisations in vivo peuvent fournir une identification et une découverte importante d'agents thérapeutiques et/ou de traitements utiles dans la prévention, l'amélioration ou la corrections de maladies ou de dysfonctionnements associés aux disruption géniques tels que les troubles neurologiques; les troubles cardio-vasculaires, endothéliaux, angiogéniques; les anomalies oculaires; les troubles immunologiques; les troubles oncologiques; les anomalies ou troubles métaboliques osseux; le troubles métaboliques lipidiques; ou les anomalies développementales.

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