Polypeptides for inducing a protective immune response...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/31 (2006.01) A61K 39/085 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2744323

Disclosed are polypeptides comprising an amino acid sequence structurally related to SEQ ID NO 1 and uses of such polypeptides and compositions thereof. SEQ ID NO 1 is a full length S. aureus sequence. A derivative of SEQ ID NO 1 containing an amino terminal his-tag was found to produce a protective immune response against S. aureus.

La présente invention porte sur des polypeptides qui comportent une séquence d'acides aminés structurellement liée à SEQ ID NO : 1 et sur des utilisations de tels polypeptides et de compositions les contenant. SEQ ID NO : 1 est une séquence de staphylocoque doré de longueur complète. Il a été démontré qu'un dérivé de SEQ ID NO : 1 contenant un marqueur his en position amino-terminale produit une réponse immunitaire de protection contre le staphylocoque doré.

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