Human bone stimulating factor

Details Human bone stimulating factor Human bone stimulating factor

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) A61K 38/18 (2006.01) C07K 14/52 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188172

Polypeptides from human blood serum have been found to increase bone growth in rats. Useful to promote bone growth in mammals, and or the treatment of osteoporosis. One polypeptide has the seventy amino acid sequence of NAP-2: Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp. The other polypeptide has the seventy-five amino acid sequence of a previously sequenced variant of NAP-2: Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu Gln Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp. Both polypeptides have been found to increase bone growth in rats.

Il a été découvert que des polypeptides provenant du sérum sanguin humain augmentent la croissance osseuse chez les rats. Ils sont donc aptes à être utilisés pour favoriser la croissance osseuse chez les mammifères et/ou pour le traitement de l'ostéoporose. L'un des polypeptides présente la séquence de soixante-dix acides aminés du peptide d'activation de neutrophiles (NAP-2): Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp. L'autre polypeptide présente la séquence de soixante-quinze acides aminés d'une variante préalablement séquencée de NAP-2: Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp. Il a été découvert que ces deux polypeptides augmentent la croissance osseuse chez les rats.

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