C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/071 (2010.01) A61L 27/38 (2006.01) C12M 3/00 (2006.01) C12M 3/04 (2006.01)
Patent
CA 2729559
Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided.
La présente invention concerne des structures et des procédés pour le génie tissulaire comprenant un corps multicellulaire comprenant une pluralité de cellules vivantes. Une pluralité de corps multicellulaires peuvent être agencés selon un motif et fusionnés pour former un tissu technique. Lagencement peut comprendre des corps de charge comprenant un matériau biocompatible qui résiste à la migration et à la croissance de cellules depuis les corps multicellulaires et qui est résistant à ladhérence de cellules à celui-ci. Des constructions tridimensionnelles peuvent être assemblées par impression ou autre empilement des corps multicellulaires et des corps de charge de sorte quil y ait un contact direct entre des corps multicellulaires contigus, de manière appropriée le long dune surface de contact qui a une longueur substantielle. Le contact direct entre les corps multicellulaires favorise une fusion efficace et fiable. La surface de contact augmentée entre des corps multicellulaires contigus favorise également une fusion efficace et fiable. La présente invention concerne en outre des procédés de production de corps multicellulaires ayant des caractéristiques qui facilitent lassemblage de constructions tridimensionnelles.
Forgacs Gabor
Marga Francoise Suzanne
Norotte Cyrille
Smart & Biggar
The Curators Of The University Of Missouri
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