Compositions and methods for increasing hdl and hdl-2b levels

Details Compositions and methods for increasing hdl and hdl-2b levels Compositions and methods for increasing hdl and hdl-2b levels

A - Human Necessities

61

K

A61K 9/20 (2006.01)

Patent

CA 2543170

The present invention provides compositions and methods for reducing flushing in a patient. In addition, compositions and methods are provided for increasing HDL and/or HDL-2b levels in a patient. In some embodiments, the compositions include an adipocyte G-protein antagonist, a PPAR-.alpha. agonist, and a PPAR-.gamma. agonist in amounts effective in to provide a synergistic therapeutic HDL increasing effect, and/or a synergistic therapeutic HDL-2b increasing effect.

Cette invention se rapporte à des compositions et à des procédés servant à réduire les bouffées vasomotrices chez un patient. Cette invention concerne en outre des compositions et des procédés servant à augmenter les niveaux de HDL et/ou de HDL-2b chez un patient. Dans certains modes de réalisation, ces compositions contiennent un antagoniste de la protéine G des adipocytes, un agoniste de PPAR-.alpha. et un agoniste de PPAR-.gamma. en quantités aptes à produire un effet d'augmentation de HDL thérapeutique synergique et/ou un effet d'augmentation de HDL-2b thérapeutique synergique.

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