C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/775 (2006.01) C12N 9/16 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/55 (2006.01) C12P 21/08 (2006.01) C12Q 1/37 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2085924
ABSTRACT cDNAs for a 104 amino acid protein with endoproteinase and acetylcholinesterase domains and for a cellular, modified, truncated version of the protein are constructed using oligonucleotide synthesis, and expressed in a prokaryotic vector. The sense-antisense relationship between the cDNAs encoding these proteins and the cDNA encoding the amyloid forming APP gene, and the similarities between the amino acid sequences deduced for the protein, and amino acid sequences in proteinases and esterases which are involved in pathogenic processes, make the proteins perfect candidates for factors that cause and maintain human Alzheimer's disease. Since the mRNAs encoding these proteins in healthy humans are repressed by mRNA encoding the normal APP gene and the gene encoding the amyloid related protein APRP363, they are potentially excellent targets for a safe, effective, immunological approach aimed at preventing, perhaps even stopping and reversing, the course of the disease.
Bergmann Johanna E.
Preddie Rick E.
Bergmann Johanna E.
Na
Preddie Rick E.
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