C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2487321
The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.
L'invention porte sur de nouvelles r~gions charpentes humaines ~ cha¹ne variable et sur des anticorps humanis~s comprenant lesdites r~gions. L'invention porte ~galement sur un nouveau proc~d~ d'identification de r~gions charpentes acceptrices dans des s~quences d'accepteurs, recourant ~ une r~tromutation pour greffer une s~quence donneuse sur une charpente humaine.
Arndt Michaela
Krauss Jurgen
Martin Andrew C. R.
Rybak Susanna
Smart & Biggar
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
The University Of Reading
LandOfFree
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