A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/47 (2006.01) A61K 31/7088 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2378883
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
L'invention concerne des techniques et des compositions représentant un progrès dans la lutte contre la résistance microbienne à l'action des médicaments. On a découvert des pompes d'écoulement de type AcrAB pour lutter contre la résistance à l'action des médicaments, même dans le cas de microbes très résistants. L'invention concerne également des techniques de traitement d'infection, des techniques de criblage d'inhibiteurs de pompes d'écoulement de type AcrAB, et des techniques permettant d'améliorer l'activité antimicrobienne des médicaments. L'invention concerne, en outre, une composition pharmaceutique comprenant un inhibiteur de pompe d'écoulement de type AcrAB, ainsi qu'un agent antimicrobien.
Levy Stuart B.
Oethinger Margaret
Borden Ladner Gervais Llp
Trustees Of Tufts College
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