C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2292900
An attenuated bacterium in which the native fur gene, or homologue thereof, is modified such that the expression of the fur gene product, or homologue thereof, is regulated independently of the iron concentration in the environment of the bacterium, is suitable for use as a live vaccine. The bacterium may be, in particular, Neisseria meningitidis.
On décrit une bactérie atténuée dans laquelle le gène fur natif ou son homologue est modifié de sorte que l'expression du produit génique fur ou son homologue est régulée indépendamment de la concentration en fer dans l'environnement de la bactérie. Cette bactérie atténuée peut être utilisée en tant que vaccin vivant. De manière plus spécifique la bactérie peut être Neisseria meningitidis.
Baldwin Thomas John
Borriello Saverio Peter
Palmer Helen Mary
Bereskin & Parr
Medical Research Council
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