Substituted benzothienylpiperazines their use as...

Details Substituted benzothienylpiperazines their use as... Substituted benzothienylpiperazines their use as...

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/495 (2006.01) C07D 333/66 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2171695

This invention relates to compounds of the formula I Image (I) wherein X is hydrogen, halogen, hydroxy, (C1-C6)alkoxy, amino or trifluoromethyl; and Y is -CN or -NR1R2; where l is an integer of 1 or 2; m is an integer of 0, 1 or 2; n is an integer of 2, 3 or 4, except when Y is CN, in which case n can also be 1; R1 is hydrogen, (C1-C6)alkyl or (C1-C6)alkylcarbonyl; R2 is hydrogen, (C1-C10)alkylcarbonyl, (C3-C12)cycloalkylcarbonyl, hydroxy- (C1-C6)alkylcarbonyl, phenylcarbonyl, thienylcarbonyl or benzothienylcarbonyl; or R1 and R2 together with nitrogen atom to which they are attached form the ring Image where A is C = O or CH2; and B is C = O, CHOH, CH2 or CH2CH2; and Z is hydrogen, halogen, hydroxy, (C1-C6)alkoxy, amino or trifluoro; and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions thereof and their use for the treatment of psychoses.

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