A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 39/00 (2006.01) A61K 39/10 (2006.01) A61K 47/34 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2731995
A method of inducing either a T H1 polarised immune response, a T H2 polarised immune response or a combined T H1 and T H2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH 1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 µm, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised T H2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B.pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
Kirby Eades Gale Baker
Merrion Research III Limited
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