Novel guanosine triphosphate (gtp)-binding protein-coupled...

Details Novel guanosine triphosphate (gtp)-binding protein-coupled... Novel guanosine triphosphate (gtp)-binding protein-coupled...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2368216

cDNAs encoding novel G protein-coupled receptor proteins originating in humans have been successfully isolated by uniquely extracting regions highly conserved in known G protein-coupled receptor proteins and effecting a screening with the use of probes corresponding thereto. Use of these G protein- coupled receptor proteins makes it possible to screen ligands or candidate compounds for drugs capable of regulating the signal transduction from receptors.

On a réussi à isoler des ADNc codant pour des protéines de récepteur couplées aux protéines G chez les humains, en procédant à une extraction unique de régions hautement conservées dans des protéines de récepteur couplées aux protéines G connues, puis en effectuant un criblage avec des sondes correspondantes. Grâce à ces protéines de récepteur couplées aux protéines G, il est possible de cribler des ligands ou des composés candidats de médicaments capables de réguler la transduction du signal à partir de récepteurs.

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