C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2221682
The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only relatively small amounts, or antigens of which only very small amounts are available or antigens which easily lose their in vivo conformation. Thus the method according to the invention comprises a series of steps, comprising a step in which B-cells from a mammal injected with surface antigen-comprising material are enriched with respect to the relative number of specific B-cells and a step which comprises a small-scale fusion technique.
Méthode efficace de production d'anticorps monoclonaux agissant contre des antigènes de surface de cellules et de virus. Elle s'applique aux antigènes qui sont présents seulement en quantité relativement petite, aux antigènes dont seulement une très petite quantité est disponible, ou aux antigènes qui perdent facilement leur conformation in vivo. Cette méthode comprend plusieurs étapes. Au cours d'une de ces étapes, des cellules B, provenant d'un mammifère à qui on a injecté une substance comprenant un antigène de surface, sont enrichies à l'égard du nombre relatif de cellules B spécifiques. Durant une autre étape, on a recours à une technique de fusion à petite échelle.
Akzo Nobel N.v.
Fetherstonhaugh & Co.
N.v. Organon
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