Brca1 mrna expression levels predict survival in breast...

Details Brca1 mrna expression levels predict survival in breast... Brca1 mrna expression levels predict survival in breast...

G - Physics

01

N

G01N 33/574 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2717690

The invention relates to methods for predicting the clinical outcome of a patient which suffers from breast cancer based on the expression levels of BRCA1, wherein low BRCA1 expression levels are indicative of a good prognosis. Moreover, the invention relates to methods for predicting the response to a neoadjuvant therapy based on a combination of an anti-metabo-lite, an intercalating agent and an alkylating agentof a patient which suffers from breast cancer based on the expression levels of BRCA1.

L'invention porte sur des procédés pour prédire le résultat clinique chez une patiente qui souffre d'un cancer du sein en fonction des taux d'expression de BRCA1, de faibles taux d'expression de BRCA1 étant indicatifs d'un bon pronostic. De plus, l'invention porte sur des procédés pour prédire la réponse d'une patiente qui souffre d'un cancer du sein à une thérapie par néo-adjuvant fondée sur une combinaison d'un anti-métabolite, d'un agent intercalant et d'un agent alkylant, en fonction des taux d'expression de BRCA1.

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