C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/56 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/395 (2006.01) C07C 233/40 (2006.01) C07C 233/73 (2006.01) C07C 233/78 (2006.01) C07C 235/34 (2006.01) C07C 235/44 (2006.01) C07C 235/48 (2006.01) C07C 235/60 (2006.01) C07C 237/32 (2006.01) C07C 237/34 (2006.01) C07C 269/04 (2006.01) C07C 271/20 (2006.01) C07C 271/28 (2006.01) C07C 311/29 (2006.01) C07D 213/82 (2006.01) C07D 215/56 (2006.01) C07D 311/22 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2206787
The present invention provides 2,5-diamino-3,4-disubstituted-1,6- diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to treat retroviral, specifically HIV and more specifically HIV-1 and HIV-2, infections in mammals, particularly humans, a method of synthesizing asymmetric DAD isosteres comprising benzamide, sulfonamide and anthranilamide subunits, and a method of using such compounds to assay new compounds for antiretroviral activity.
L'invention concerne des composés isostères de 2,5-diamino-3,4-disubstitués-1,6-diphénylhexane (DAD) comprenant des sous-unités de benzamide, de sulfonamide et d'anthranilamide, une composition pharmaceutique à base de ces composés, un mode d'utilisation de ces composés dans le traitement des infections à rétrovirus chez les mammifères, notamment les infections à VIH et plus particulièrement les infections à VIH-1 et à VIH-2 chez l'homme, un procédé de synthèse des isostères DAD dissymétriques comprenant des sous-unités de benzamide, de sulfonamide et d'anthranilamide, ainsi que le mode d'emploi de ces composés pour le dosage de nouveaux composés ayant une activité antirétrovirus.
Erickson John W.
Randad Ramnarayan S.
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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