A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 25/04 (2006.01) A61B 17/34 (2006.01)
Patent
CA 2301545
In a method and apparatus for delivering a composition to a targeted area of tissue, exposure of a non-targeted tissue to the composition is minimized. The apparatus (10) has at least one needle-like shaft (40) which is inserted through a track in the non-targeted tissue to deliver the composition to the targeted tissue through an opening (22) in the shaft. The track may be a naturally occurring lumen in a tissue, such as a vascular lumen, or may be a track created surgically by a diagnostic instrument, or by the needle-like shaft (40) of the present apparatus. A valve-like mechanism (38) closes the opening (22) in the shaft to prevent premature delivery of the composition during insertion of the shaft, and to prevent loss of composition during withdrawal of the shaft. The valve-like mechanism (38) also prevents excessive delivery of the composition to targeted tissue. An annular dam (39) is mounted on an exterior portion of the shaft near the opening. When the opening in the shaft has been suitably positioned in the targeted tissue, the dam is radially expanded to prevent quantities of composition intended for delivery to the targeted tissue from flowing away from the targeted tissue along the track though which the shaft is inserted.
La présente invention concerne un procédé et un appareil d'administration d'une composition à une zone cible de tissu, l'exposition d'un tissu non ciblé à cette composition étant réduite. L'appareil comprend au moins un axe de type aiguille inséré dans un passage du tissu non ciblé de façon à administrer la composition au tissu cible par une ouverture de l'axe. Le passage peut être une lumière naturelle telle qu'une lumière de vaisseau ou un passage créé chirurgicalement par un instrument de diagnostic ou par l'axe de type aiguille dudit appareil. Un mécanisme de type soupape ferme l'ouverture de l'axe de façon à empêcher une administration prématurée de la composition lors de l'insertion de cet axe, ou la perte de composition lors du retrait de cet axe. Le mécanisme de type soupape empêche également une administration excessive au tissu cible. Une barrière annulaire est montée sur une partie externe de l'axe, près de l'ouverture. Lorsque l'ouverture de l'axe est convenablement positionnée dans le tissu cible, la barrière se dilate radialement de façon à empêcher l'écoulement à partir de ce tissu, le long du passage à travers lequel l'axe est inséré, de quantités de composition destinées à être administrées au tissu cible.
Decrescito Vincent
Kronenthal Richard
Mcbeth Dean
Direct Therapeutics Inc.
Robic
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