C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 3/075 (2006.01) A61L 24/04 (2006.01) A61L 27/52 (2006.01) C08B 37/00 (2006.01) C08G 65/326 (2006.01) C08G 69/48 (2006.01) C08H 1/06 (2006.01)
Patent
CA 2692553
This invention discloses a preparation method for biocompatible rapid-gelating hydrogel. Wherein, hydrogel is formed by rapid chemical-crosslinking using the mixing and chemical-crosslinking reaction under specified conditions between several active compound components. The preparation method comprises the following steps: (1) The solution containing biocompatible thiolated macromolecular derivatives (component A) and biocompatible thiol reactive crosslinking agents (component B) mutually mix to form reactive mixture with specified crosslinking conditions; (2) the reactive mixture forms the hydrogel. The invention also discloses a preparation method for novel rapid-gelating hydrogel spray and an application in medical field. This invention has the advantages of good biocompatibility, no by-products, good stability, convenient use, small amount of raw materials used, suitable for many medical application, etc..
L'invention porte sur un procédé pour la formation rapide d'un hydrogel biocompatible. Le procédé met en jeu le mélange d'un composant A et d'un composant B pour former un mélange réactif ayant des conditions de réticulation spécifiques, puis le mélange forme un hydrogel biocompatible par réticulation rapide. Le composant A est une solution de dérivés de sulfhydryle d'un polymère biocompatible. Le composant B est un agent de réticulation réactif avec le sulfhydryle, biocompatible. Un agent de pulvérisation qui est apte à former rapidement un hydrogel est préparé. Et l'invention porte sur les utilisations de l'agent de pulvérisation dans le domaine de la médecine.
Bioregen Biomedical (changzhou) Co. Ltd.
Gowling Lafleur Henderson Llp
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