Production and use of type 5 17beta-hydroxysteroid...

Details Production and use of type 5 17beta-hydroxysteroid... Production and use of type 5 17beta-hydroxysteroid...

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01) C12N 9/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/32 (2006.01)

Patent

CA 2232500

A novel type 5 17.beta.-hydroxysteroid dehydrogenase is provided. Methods of producing the enzyme and using the enzyme to identify potential compounds which inhibit or alter the activity of the enzyme are described. In addition, methods of using the gene sequence or portions thereof for probes or to produce expression-disrupting sense or antisense DNA fragments thereof, or antisense RNA, are provided.

Est décrite nouvelle déshydrogénase 17.beta.-hydroxystéroïde type 5. Sont également décrits des procédés de production, et d'utilisation de l'enzyme pour l'identification de composés potentiels inhibant ou modifiant l'activité de l'enzyme. De plus, l'invention concerne des procédés d'utilisation de la séquence de gènes ou de parties de celle-ci pour des sondes ou pour la production de fragments d'ADN sens ou antisens de celle-ci, ou d'ARN antisens, interrompant l'expression.

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