C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/4196 (2006.01) A61P 35/00 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2618628
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
La présente invention concerne des dérivés substitués de triazole ainsi que des compositions comprenant des dérivés substitués de triazole. La présente invention concerne en outre des méthodes d'inhibition de l'activité de Hsp90 chez un patient nécessitant un tel traitement, ainsi que des méthodes de traitement prophylactique ou thérapeutique de troubles hyperprolifératifs, tels que le cancer, chez un patient nécessitant un tel traitement, lesdites méthodes comprenant l'administration au patient d'un dérivé substitué de triazole selon l'invention, ou d'une composition comprenant un tel dérivé.
Barsoum James
Chae Junghyun
Chimmanamada Dinesh U.
Du Zhenjian
Foley Kevin
Gowling Lafleur Henderson Llp
Synta Pharmaceuticals Corp.
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