Method for the preparation of pre-filled plastic syringes

Details Method for the preparation of pre-filled plastic syringes Method for the preparation of pre-filled plastic syringes

B - Operations, Transporting

65

B

B65B 3/02 (2006.01) A61M 5/178 (2006.01) A61M 5/28 (2006.01) B65B 3/00 (2006.01) A61M 5/00 (2006.01) A61M 5/31 (2006.01)

Patent

CA 2151482

A novel method for the preparation of a pre-filled plastic syringe, and preferably the preparation of a plastic syringe pre-filled with a diagnostic contrast agent wherein said syringe comprises as components a barrel (1), a tip seal (3) capable of sealing the nozzle of the barrel and a piston (5) capable of sliding in the barrel and sealing the open end of the barrel opposite the nozzle, comprising the steps of: (a) providing at least one component of said syringe which is molded under conditions which are substantially free of pyrogens and viable and non-viable particulates; and (b) filling and assembling said syringe.

L'invention concerne un nouveau procédé de préparation d'une seringue en plastique préalablement emplie, de préférence d'une seringue préalablement emplie d'un agent de contraste diagnostique, cette seringue étant composée d'un corps de pompe (1), d'un tampon d'extrémité (3) pouvant assurer l'étanchéité de la buse du corps de pompe, ainsi que d'un piston (5) pouvant coulisser dans le corps de pompe et assurer l'étanchéité de l'extrémité ouverte du corps de pompe située à l'opposé de la buse, ce procédé comprenant les étapes consistant : (a) à produire au moins une des parties composant cette seringue par moulage dans des conditions sensiblement apyrogènes et libres de matières particulaires viables et non viables, et (b) à remplir et assembler cette seringue.

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