Compositions for modulating intracellular inositol...

Details Compositions for modulating intracellular inositol... Compositions for modulating intracellular inositol...

A - Human Necessities

61

K

A61K 31/685 (2006.01) A61K 31/13 (2006.01) A61K 31/688 (2006.01) A61K 31/70 (2006.01) A61K 31/7032 (2006.01) C12Q 1/44 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2241004

Compositions and methods for the modulation of aberrant inositol trisphosphate concentration in neurons is disclosed. Inositol trisphosphate stimulates an increase in intraneuronal calcium ion concentration which can, if unregulated, lead to acute neurotoxicities following such insults as brain seizures, and brain anoxia/ischemia; and lead to chronic neurotoxicities in such diseases as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Inhibited inositol trisphosphate production results in aberrantly low calcium ion levels leading to neuronal apoptosis. The figure illustrates conversion of phosphitidyl inositol 4,5-biphosphate into diacylglycerol and inositol trisphosphate.

L'invention concerne des compositions et des procédés pour moduler la concentration de triphosphate d'inositol aberrante dans les neurones. Le triphosphate d'inositol stimule une augmentation de la concentration intraneuronale des ions calciques qui, lorsqu'elle n'est pas régulée, risque de se traduire par des neurotoxicités aigües après des accidents cérébraux comme, par exemple, des crises d'épilepsie, et une anoxie/ischémie cérébrale ou par des neurotoxicités chroniques dans des maladies telles que la maladie d'Alzheimer, la chorée de Huntington, la maladie de Parkinson et la sclérose latérale amyotrophique. La production inhibée de triphosphate d'inositol se traduit par des taux d'ions calciques beaucoup trop faibles, pouvant se traduire par une apoptose neuronale. La figure montre la conversion de biphosphate-4,5 d'inositol phosphitidyle en diacylglycérol et triphosphate d'inositol.

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