Engineered antibody-stress protein fusions

Details Engineered antibody-stress protein fusions Engineered antibody-stress protein fusions

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 49/00 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/35 (2006.01) C07K 16/00 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2640671

Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non- mammalian cells, such as E. coli.

L'invention concerne des polypeptides de fusion comprenant un anticorps de synthèse et une protéine de stress. Ces polypeptides se lient aux antigènes avec une haute affinité, sont fortement immunogènes, présentent un amorçage de MHC de classe I et peuvent être produits dans des cellules non mammifères, et notamment dansE. coli.

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