A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 31/70 (2006.01) A61K 47/32 (2006.01) A61M 5/00 (2006.01)
Patent
CA 2304134
A method for administering a drug to a selected site in a patient includes the steps of (a) administering a composition including a micellar drug carrier having a hydrophobic core and an effective amount of the drug disposed in the hydrophobic core; and (b) applying ultrasonic energy to the selected site such that the drug is released from the hydrophobic core to the selected site. Preferably, the drug carrier is a triblock copolymer, such as a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer having a molecular weight of about 6500. The drug is preferably an antineoplastic agent such as doxorubicin.
Procédé de libération d'un médicament dans un site prédéterminé chez un patient, qui consiste (a) à administrer une composition contenant un vecteur de médicament micellaire ayant un noyau hydrophobe et une dose efficace du médicament placée dans ledit noyau; et (b) à appliquer de l'énergie ultrasonore sur le site sélectionné de sorte que le médicament soit libéré par le noyau hydrophobe sur le site sélectionné. Le vecteur de médicament est, de préférence, un copolymère tribloc, comme un copolymère bloc de poly(éthylène oxyde)-poly(propylène oxyde)-poly(éthylène oxyde) ayant un poids moléculaire d'environ 6500. Ledit médicament est de préférence un agent antinéoplasique comme la doxorubicine.
Pitt William G.
Rapoport Natalya
Brigham Young University
Smart & Biggar
University Of Utah Research Foundation
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