A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) C07K 16/28 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2153776
The transendothelial migration of leukocytes and other cells during acute and/or chronic inflammation can be inhibited by the administration of anti-PECAM-1 reagents. In particular, transendothelial migration appears to be mediated by the activity of platelet endothelial cell adhesion molecule (PECAM); as inhibition of neutrophil and monocyte TEM occurs in the presence of recombinant soluble PECAM or a monoclonal anti-PECAM antibody. Methods for controlling transendothelial migration and corresponding agents are disclosed, as arc related diagnostic methods and drug discovery assays. Inhibition of such transendothelial migration will play a role in the prevention and/or diminishment of organ damage in inflammation, and the present method may be especially useful in the treatment of chronic inflammation, as well as in treating acute inflammation.
Rockefeller University (the)
Swabey Ogilvy Renault
LandOfFree
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