C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2644356
The present invention relates to the discovery that certain compounds inhibit, regulate and/or modulate tyrosine and serine/threonine kinase and kinase-like proteins, such as RAF kinase, a serine/threonine kinase that functions in the MAP kinase signaling pathway, and is concerned with compositions which contain these compounds, and methods of using them to treat tyrosine and serine/threonine kinase and kinase-like dependent diseases, such as angiogenesis, cancer and cardiac hypertrophy. (Formula I).
La présente invention est liée à la découverte que certains composés inhibent, régulent et/ou modulent la tyrosine, la sérine/ thréonine kinase et des protéines de type kinase telles que la kinase RAF, une sérine/ thréonine kinase qui fonctionne sur la voie de signalisation kinase MAP, et concerne des compositions contenant ces composés, ainsi que des procédés d'utilisation des compositions pour le traitement de maladies liées à la tyrosine, à la sérine/ thréonine kinase et à des protéines de type kinase, telles qu'angiogenèse, cancer et hypertrophie cardiaque.
Batt David Bryant
Beerli Rene
Bold Guido
Caravatti Giorgio
Ramsey Timothy Michael
Fetherstonhaugh & Co.
Novartis Ag
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