Nitrated heterocyclic compounds as endothelin receptor...

Details Nitrated heterocyclic compounds as endothelin receptor... Nitrated heterocyclic compounds as endothelin receptor...

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5415 (2006.01) C07D 239/34 (2006.01) C07D 239/60 (2006.01) C07D 261/14 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2652636

Endothelin receptor antagonist nitroderivatives of general formula (I) having an improved pharmacological activity compared with their parent compounds. They can be employed for treating or preventing endothelial-related disorders, renal, pulmonary, cardiac and vascular diseases, and inflammatory processes.

La présente invention porte sur des dérivés nitro, antagonistes de récepteur d'endothéline, de formule générale (I) : formule (I), d'activité pharmacologique améliorée par rapport à leurs composés parents. Ils peuvent être employés dans le traitement prophylactique ou thérapeutique de troubles de type endothélial, de maladies rénales, pulmonaires, cardiaques et vasculaires, et de processus inflammatoires.

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