Hsv primase inhibitors

Details Hsv primase inhibitors Hsv primase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 237/42 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/4402 (2006.01) A61K 31/4453 (2006.01) A61K 31/522 (2006.01) A61P 31/22 (2006.01) C07C 235/00 (2006.01) C07C 235/60 (2006.01) C07C 235/62 (2006.01) C07C 235/64 (2006.01) C07D 213/30 (2006.01) C07D 213/40 (2006.01) C07D 295/18 (2006.01)

Patent

CA 2363690

The invention provides compounds of formula (1) that are active against the HSV primase enzyme: wherein R1 is hydroxy or amino; R2 is hydrogen, halo, (C1-4)alkyl or (C1-4)alkoxy; R3 is hydrogen, halo, (C1-4)alkyl, (Cl-4)alkoxy, amino or azido; R4 has the same significance as R2; R5 is hydrogen or (C1-4)alkyl; and R is (C1- 7)alkyl, (C3-6)cycloalkyl, {phenyl(C1-7)alkyl}, {phenyl(C1-7)alkoxy}, {{(monocyclic heterocyclo)-{(C1-7)alkoxy}}, CH(W)C(O){O- (C1-4)alkyl} wherein W is hydrogen or (C1-7)alkyl, or (a) wherein Y is hydrogen or (C1-7)alkyl, and Z is (C1-7)alkyl, (C3-6) cycloalkyl, {(C3-6)cycloalkyl}-{(C1-7)alkyl}, phenyl(C1-7)alkyl or {{(monocyclic heterocyclo)-{(C1-7)alkyl}}, or Y and Z together with the nitrogen atom to which they are attached represent, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 1-(4-methylpiperazinyl); with the provisos that (1) when R is CH(W)C(O)-{O-(C1-4)alkyl} as defined herein, then R5 is hydrogen; and (2) at least one of R2, R3 and R4 is other than hydrogen.

L'invention concerne des composés de la formule 1 qui agissent à l'encontre de l'enzyme de la primase du virus herpès simplex, formule dans laquelle R1 désigne hydroxy ou amino; R2 désigne hydrogène, halo, alkyle(C1-4) ou alcoxy(C1-4); R3 désigne hydrogène, halo, alkyle(C1-4), alcoxy(C1-4), amino ou azido; R4 a la même signification que R2 ; R5 désigne hydrogène ou alkyle(C1-4); et R désigne alkyle(C1-7), cycloalkyle(C3-6), {phényle(C1-7)alkyle}, {phényle(C1-7)alcoxy}, {{(hétéocyclo monocyclique)-alcoxy(C1-7)}}; CH(W)C(O){O-alkyle(C1-4)} où W désigne hydrogène ou alkyle(C1-7) ou (a) où Y désigne hydrogène ou alkyle(C1-7), et Z désigne alkyle(C1-7), cycloalkyle(C3-6), {cycloalkyle(C3-6)}-{alkyle(C1-7)}, phényle(C1-7)alkyle ou {{hétérocyclo monocyclique)-{alkyle(C1-7)}}, ou Y et Z désignent conjointement avec l'atome d'azote auquel ils sont liés, 1-pyrrolidinyle, 1-pipéridinyle, 4-morpholinyle ou 1-(4-méthylpipérazinyle); sous réserve que (1) si R désigne CH(W)C(O)-{O-(alkyle(C1-4)} comme défini précédemment, R<5> désigne alors hydrogène; et (2) qu'au moins un des restes R2,R3 et R4 soit différent d'hydrogène.

Affiliated with

Also associated with

Rating

Hsv primase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hsv primase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hsv primase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2077782