Methods of preparing polymers having terminal amine groups

Details Methods of preparing polymers having terminal amine groups Methods of preparing polymers having terminal amine groups

C - Chemistry, Metallurgy

08

G

C08G 79/02 (2006.01) C08G 79/08 (2006.01)

Patent

CA 2618701

The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

L'invention concerne des procédés de préparation de polymères linéaires tels que des oxydes de polyalkylène contenant une amine terminale à haut degré de pureté. Le procédé préféré comporte les étapes consistant à: faire réagir dans un solvant un oxyde de polyalkylène tel que le polyéthylène glycol contenant un azoture terminal, avec un agent réducteur à base de phosphine tel que la triphénylphosphine, ou un agent réducteur de borohydrure de métal alcalin tel que le borohydrure de sodium, de manière à produire un reflux. Les composés polymères-amines ainsi obtenus présentent une pureté suffisante, et rendent ainsi superflues les coûteuses et laborieuses étapes de purification requises pour des polymères de qualité pharmaceutique.

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