C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/06 (2006.01) C07D 477/02 (2006.01) C07D 477/14 (2006.01)
Patent
CA 2336997
The invention describes an improved process for synthesizing 1-.beta.-methyl-2- hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention.
La présente invention concerne un procédé perfectionné utilisé pour synthétiser des carbapenems substitués par 1-.beta.-méthyl-2-hydroxyméthyle comme intermédiaires clés pour la synthèse d'antibiotiques carbapenems anti-MRSA. La synthèse supprime l'utilisation de BU¿3?SnCH¿2?OH et de HMPA, qui sont des substances toxiques ne pouvant pas faire l'objet d'une production à échelle industrielle. Cette invention concerne par ailleurs ces nouveaux intermédiaires.
Jensen Mark S.
Wells Kenneth M.
Xiao Yi
Yang Chunhua
Yasuda Nobuyoshi
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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