2,3-diaryl- or heteroaryl-substituted...

Details 2,3-diaryl- or heteroaryl-substituted... 2,3-diaryl- or heteroaryl-substituted...

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61K 31/465 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/536 (2006.01) A61K 31/5415 (2006.01) A61P 3/10 (2006.01) C07C 255/54 (2006.01) C07D 213/80 (2006.01) C07D 235/26 (2006.01) C07D 263/58 (2006.01) C07D 285/14 (2006.01) C07D 413/10 (2006.01) C07D 455/02 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2754176

The present invention relates to compounds of formula (I), wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

La présente invention concerne des composés de formule (I), dans laquelle R1a à R1e, R2, R3 et R5 sont tels que définis dans la description et les revendications et R4 représente un groupe hétéroaryle ou cyanophényle bicyclique, ainsi que leurs sels pharmaceutiquement acceptables. Les composés sont des antagonistes du récepteur des glucocorticoïdes utiles pour le traitement et/ou la prévention de maladies telles que le diabète, la dyslipidémie, l'obésité, l'hypertension, les maladies cardiovasculaires, le déséquilibre surrénalien ou la dépression.

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