C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 19/00 (2006.01) C12M 1/00 (2006.01) C12N 15/09 (2006.01) G01N 21/78 (2006.01) G01N 27/62 (2006.01) G01N 27/64 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) G01N 33/60 (2006.01) G01N 37/00 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2442232
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of hematopoietic cell proliferative disorders, or the predisposition to hematopoietic cell proliferative disorders.
L'invention porte sur des séquences modifiées et génomiques, sur des oligonucléotides et/ou des oligomères PNA permettant de détecter l'état de méthylation de cytosine de l'ADN génomique, ainsi que sur un procédé de vérification des paramètres génétiques et/ou épigénétiques des gènes utilisés dans la différentiation, le diagnostique, le traitement et/ou la surveillance des troubles de la prolifération des cellules hématopoïétiques, ou la prédisposition aux troubles de prolifération des cellules hématopoïétiques.
Adorjan Peter
Lesche Ralf
Lipscher Evelyne
Maier Sabine
Model Fabian
Epigenomics Ag
Macrae & Co.
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